I first tried Cryoderm after buying a bottle of the roll on from my chiropractors office. I used to buy Biofreeze all the time. I really liked the fact that all the ingredients are all natural and was already aware of the healing properties of Arnica, MSN and Bosweilla. I was VERY impressed at how fast it started working and how long the relief lasted (about 4 hrs) I will never buy Biofreeze again! I have never had anything else work so well on m y pain and I love that it's available in a rollon, spray and a gel. I use all 3 depending on where my pain is. I have fibromyalgia. RA, OA, total spine pain from neck to tailbone and am in pain 24/7, so I am grateful to have this product in my home.