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Integrative Therapeutics Active B-Complex is a balanced, hypoallergenic B-complex formula featuring the active forms of vitamins B2, B6, and B12. It also contains Quatrefolic, the stabilized glucosamine salt of (6S)-5-methyltetrahydrofolate, a reduced and active form of folic acid.
Optimal folate and B vitamin intake is associated with healthy neurological function as well as cardiovascular support.
Because humans cannot synthesize folates, they must obtain them from dietary sources. (6S)-5-methyl-tetrahydrofolate (known as 5-MTHF or L-methylfolate) is the predominant form of dietary folate and the only species normally found in the circulation, and thus it is the folate normally transported into peripheral tissues for use in cellular metabolism.
Cellular metabolism of L-methylfolate begins with conversion to unsubstituted tetrahydrofolate in what is known as the “methylation cycle.” There is some evidence that the metabolic capacity of intestinal cells to reduce folic acid may be limited in some individuals. Quatrefolic is a novel form of folate that is stabilized as a salt of
glucosamine. It is estimated to be 100 times more soluble than the commonly used calcium salt of 5-MTHF.4 Supplementation with the folate derivative is thought to confer the benefi cial effects associated with folic acid, but without requiring the body to convert it from folic acid.
Each B vitamin has a unique structure and performs vital, unique functions in the human body.
Vitamin B1 (thiamine) is involved in numerous body functions,
including nervous system and muscle functioning; the flow
of electrolytes in and out of nerve and muscle cells; various
enzyme processes; carbohydrate metabolism; and the
production of hydrochloric acid in the stomach.
Vitamin B2 (riboflavin) is involved in vital metabolic processes
in the body and is necessary for normal cell function, growth,
and energy production.
Vitamin B3 (niacin, niacinamide) is metabolized to form
niacinamide adenine dinucleotide (NAD), niacinamide adenine
dinucleotide phosphate (NADP), and nicotinuric acid, all
coenzymes necessary for cell function.
Vitamin B6 (pyridoxine) is required for the synthesis of the
neurotransmitters serotonin and norepinephrine, for myelin
formation, and for amino acid metabolism.
Vitamin B12 (Cobalamin) exists in the body in coenzyme forms
that are active in cardiovascular, neurological, gastrointestinal,
musculoskeletal, and other body systems.
Folates play a role in the synthesis of DNA and RNA, as well
as being involved in homoctysteine and vitamin B12
metabolism. Folates are also needed for optimal functioning
of the central nervous and immunological systems.
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Directions: Take 1 or 2 capsules daily with meals, or as recommended by your healthcare professional.
Other Ingredients: vegetable capsule (hydroxypropyl methylcellulose), cellulose, calcium laurate, silicon dioxide.
No gluten, soy, or dary products.
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