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Thorne Research - 5-Hydroxytryptophan - 90 Capsules

Thorne Research - 5-Hydroxytryptophan - 90 Capsules

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Helps increase serotonin levels to support sleep and stress management.


Thorne Research 5-Hydroxytryptophan

Supports Sleep and Stress Management

Well Absorbed - 90 Capsules

5-Hydroxytryptophan (5-HTP) is the intermediate metabolite produced when the body initiates the process of converting the essential amino acid L-tryptophan to serotonin. Serotonin levels in the body are associated with the regulation of sleep, mood, aggression, appetite, temperature, sexual behavior, and pain sensation.

Supplementing with 5-HTP to facilitate serotonin production is preferable to supplementing with L-tryptophan because, unlike L-tryptophan, 5-HTP cannot be shunted into niacin or protein production. Supplementation with 5-HTP bypasses the conversion of L-tryptophan into 5-HTP by the enzyme tryptophan hydroxylase, the rate-limiting step in the synthesis of serotonin and a step that can be inhibited by a number of factors, including stress, insulin resistance, increasing age, and deficiencies of vitamin C, folate, and iron.

Enhances Serotonin Production

  • Increases serotonin levels for sleep enhancement, decreased sugar cravings, and better stress management
  • Can be taken with meals without competing with other amino acids
  • Includes vitamin B6 for optimal activity
  • Made without flowing agents that can inhibit bioavailability

5-HTP is well absorbed when taken orally, with about 70 percent ending up in the bloodstream.

Intestinal absorption of 5-HTP does not require the presence of a transport molecule and is not affected by the presence of other amino acids; therefore, it may be taken with meals without reducing its effectiveness. 5-HTP easily crosses the blood-brain barrier and effectively increases central nervous system (CNS) synthesis of serotonin.

5-HTP has been shown to have a beneficial impact on mood, discomfort associated with fatigue, sleep, and carbohydrate craving. Numerous studies of individuals with negative mood status have shown significant positive response with 50-300 mg of 5-HTP daily.

To further facilitate serotonin production, Thorne Research's 5-HTP formula contains pyridoxal 5'-phosphate, the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin. 5-HTP is commercially produced by extraction from the seeds of the African plant, Griffonia simplicifolia.

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Additional Information

Additional Information


Suggested Use: Take 1-2 capsules three times daily or as recommended by a health-care practitioner.

Supplement Facts
Serving Size: 2 Capsules
Servings per Container: 45
Amount Per Serving %DV1
Vitamin B6 (as pyridoxal 5-phosphate) 6.8 mg 340%
5-hydroxytryptophan 100 mg *

Other Ingredients: Microcrystalline cellulose, hypromellose (derived from cellulose) capsule, leucine, silicon dioxide.

SKU Thorne-Research-SA503-3026
UPC Code 693749503026