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Integrative Therapeutics Calcium D-Glucarate is a form of D-glucaric acid complexed with calcium. Calcium D-Glucarate promotes healthy estrogen metabolism and supports the body's ability to detoxify.
Calcium D-Glucarate is a form of D-glucaric acid complexed with calcium. It has been shown to support immune system function, promote estrogen metabolism and enhance the body's detoxification systems through inhibition of beta-glucuronidase.
Calcium D-glucarate is the calcium salt of D-glucaric acid. Naturally occurring both in the human body and in certain plant sources, supplementation with calcium D-glucarate has been shown to raise blood levels of D-glucaro-1,4-lactone and subsequently to inhibit beta-glucuronidase, an enzyme that deconjugates glucuronidated estrogen and other metabolites in the intestine. These effects support healthy metabolism of estrogen and other metabolites of Phase 2 liver detoxication.
Calcium D-glucarate supports glucuronidation, a conjugation process that occurs in the liver to metabolize hormones such as estrogen, and toxins, by binding them to glucuronic acid and then excreting the compound in bile. This process can be disrupted by beta-glucuronidase, an enzyme produced by intestinal bacteria. Beta-glucuronidase breaks the chemical bonds established between glucuronic acid and the conjugated hormones or toxins. As a result, the hormone or toxin can be liberated and reabsorbed via the enterohepatic recirculation, instead of being excreted. Beta-glucuronidase activity has been the subject of basic science studies regarding immune and hormone metabolism.
Calcium-D-glucarate also inhibits protein tyrosine kinase-C activity and induces transformation growth factor beta. Calcium D-glucarate continues to be a promising compound in clinical studies.
In an animal model, a calcium D-glucarate supplemented diet was administered after treatment with a toxin. Supplementation was found to substantially lower beta-glucuronidase levels and increase excretion of the toxin.
In a six-week clinical trial in humans, participants received an escalating dose of calcium D-glucarate, beginning with 1.5 g and increasing to 9 g per day. The level of D-glucaric acid was measured at baseline and at study completion. All groups experienced a significant rise in serum D-glucaric acid over the course of the study.* Serum levels of beta-glucuronidase were also measured and found to decrease significantly as the dosage of calcium D-glucarate increased, an indication of the beneficial role of calcium D-glucarate supplementation. Furthermore, calcium D-glucarate was found to be well-tolerated, even at the highest dosage.
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Directions: Take 1 to 3 capsules three times daily with meals, or as recommended by your healthcare professional.
Other Ingredients: vegetable capsule (modified cellulose), cellulose, modified cellulose gum, and magnesium stearate
No artificial coloring, artificial flavoring, corn, dairy products, gluten, ingredients of animal origin, preservatives, salt, soy, sugar, wheat or yeast.
This product contains natural ingredients; color variations are normal