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Nutri-E 400 Forte
Rich in Gamma-Tocopherol
Nutri E-400™ Forte by Douglas Laboratories® contains 400 I.U. of 100% natural, unesterified vitamin E (dalpha-
tocopherol), as well as a guaranteed minimum of the d-beta, d-gamma and d-delta tocopherols, which is
unique among most mixed tocopherol products available. No synthetic vitamin E is used.
Vitamin E is the collective term including four fat-soluble, natural compounds with similar chemical structure;
alpha-, beta-, gamma-, and delta-tocopherol. Of these, alpha-tocopherol has the highest nutritional activity.
Eight structural isomers of alpha-tocopherol are possible, but only the d-alpha-tocopherol (RRR-alphatocopherol)
occurs in nature. The other seven isomers have less nutritional activity, and are present only in
synthetic vitamin E (dl-alpha-tocopherol) Douglas Laboratories' Nutri E-400™ Forte softgels contain only
natural isomers of vitamin E, including d-alpha, d-beta, d-gamma, and d-delta tocopherols.
While the d-alpha isomer is the most well-known form of vitamin E, recent scientific evidence indicates that
gamma-tochoperol may possess unique, distinguishable features. This tocopherol is the major form of vitamin
E in seeds and in the US diet, though has not been studied as broadly as has alpha-tocopherol. Numerous
studies have shown gamma-tocopherol to have excellent antioxidant abilities that complements the antioxidant
ability of alpha-tocopherol. Additionally, some studies have shown that high dose supplementation of alphatocopherols
can deplete both plasma and tissue levels of gamma-tocopherol in the body.
Vitamin E is one of the body's most important antioxidant nutrients. Antioxidants protect healthy cells from
oxidative and free radical damage. Free radicals are unstable chemicals formed in the body during
metabolism and from exposure to environmental sources, such as pollution and cigarette smoke. Free
radicals are necessary for energy metabolism and immune function, but when an excessive number of free
radicals are formed, they can attack healthy cells, especially cell membrane lipids and proteins. This, in turn,
is thought to contribute to a number of degenerative diseases. Vitamin E is an especially valuable antioxidant
in the cell membranes, where it prevents oxidation of unsaturated fatty acids by trapping free radicals. This
helps stabilize and protect cell membranes, especially red blood cells and tissues sensitive to oxidation, such
as the lungs, eyes, and arteries. Vitamin E also protects the liver and other tissues from the free-radical
damage of toxicants, such as mercury, lead, ozone, nitrous oxide, carbon tetrachloride, benzene, cresol, and
various drugs. Related to its antioxidant properties, vitamin E is important for normal immune function, and
many studies show that it prevents lipid peroxidation of blood lipoproteins, such as LDL-cholesterol.
Nutri E-400™ Forte is different from most mixed tocopherols products because it contains natural mixed
tocopherols with a minimum guaranteed amount of the d-beta, d-gamma and d-delta tocopherols. Studies
have shown that these natural isomers may have added synergistic effects in conjunction with the more
commonly used d-alpha tocopherol.