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Douglas Laboratories - D-Replete - 2 Bottle Program

Douglas Laboratories - D-Replete - 2 Bottle Program
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A vitamin D repletion program*
*Results May Vary
Made by Douglas Laboratories
*Results May Vary

Douglas Laboratories - D-Replete

A Vitamin D Repletion Program

D-Sorb & Vitamin D 5000 IU - 2 Bottles

Douglas Laboratories D-Replete is a supplemental program to help maintain serum vitamin D concentrations of 25(OH)D in the sufficient range, defined as > 50 nmol/L. The program includes 2 bottles of Douglas Laboratories' vitamin D products in one box: D-Sorb™ and Vitamin D 5000 IU. D-Sorb ™ is a unique product containing 12,500 IU of vitamin D3 in a patented, self-assembling nano-colloid system for enhanced absorption.

The D-Replete program starts the patient on a 12,500 IU dose of a highly absorbable form of vitamin D for one month (dosing can be modified accordingly by the healthcare professional), and then shifts the patient to a maintenance dose of 5,000 IU daily for 3 months. It is suggested to test serum 25(OH)D levels before and after completion of this program. Monitoring of serum levels will help determine the appropriate level of supplemental vitamin D that the patient will need to maintain optimal health.


Vitamin D, also known as the "sunshine vitamin" is an essential vitamin that plays many important roles in the proper functioning of the body. Though classified as a vitamin, vitamin D is actually a key regulatory hormone for multiple physiological systems: bone calcium, immune, pancreas, cardiovascular, muscle and brain systems.

Vitamin D obtained from sun exposure, food, and supplements is biologically inert and must undergo two hydroxylations in the body for activation. The first occurs in the liver and converts vitamin D to 25- hydroxyvitamin D [25(OH)D], also known as calcidiol. The second occurs primarily in the kidney and forms the physiologically active 1,25 dihydroxyvitamin D [1,25(OH)2D], also known as calcitriol. Serum concentration of 25(OH)D is the best indicator of vitamin D status but optimal levels for bone and general health have not been established. Low serum concentrations of 25(OH)D may be associated with deficiency and suboptimal overall health.

A committee of the Institute of Medicine reviewed the data on vitamin D needs and concluded that persons are at risk of vitamin D deficiency at serum 25(OH)D concentrations <30 nmol/L (<12 ng/mL). Some are potentially at risk for inadequacy at levels ranging from 30-50 nmol/L (12-20 ng/mL). Practically all people are sufficient at levels ≥50 nmol/L (≥20 ng/mL); the committee stated that 50 nmol/L is the serum 25(OH)D level that covers the needs of 97.5% of the population. Serum concentrations >125 nmol/L (>50 ng/mL) are associated with potential adverse effects.

VESIsorb technology to deliver vitamin D3 and therefore enhance absorption. When mixed with an aqueous system, this patented technology results in the formation of a nano-colloid containing solubilized vitamin D. This colloid delivery system contains a highly uniform distribution of droplets that are less than 100 nm in diameter. The size and structure of these droplets allow for enhanced solubility and absorption of vitamin D. Douglas Laboratories' Vitamin D 5000 IU tablets are tested for disintegration and meet the USP testing standards to disintegrate in the stomach within 30 minutes. Vitamin D tablets should be taken with foods containing fat to enhance absorption.


D-Replete may be a useful dietary supplement program for those who need to replete vitamin D to healthy serum levels.

SIDE EFFECTS: No adverse effects have been reported. Note: People consuming more than 2,000 IU per day should have their vitamin D blood levels monitored by a healthcare professional.

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Additional Information
SKU DouglasLabs-66130-2X-7959

Directions: Adults take 1 D-Sorb™ Caplique® capsule daily with a meal or as directed by your healthcare professional. Once this bottle is finished, start 1 Vitamin D 5000 IU tablet daily with a meal or as directed by your healthcare professional.

Storage: Store in a cool, dry place, away from direct light. Keep out of reach of children.

Supplement Facts
Serving Size: 1 Caplique® capsule
Servings per Container: 30
Amount Per Serving %DV
Vitamin D-3 (cholecalciferol) 12,500 IU 3,125%

Other Ingredients: Cellulose (capsule) medium chain triglycerides, polysorbate 80, sucrose fatty acid esters, fatty acids, vitamin E (as dl-alpha-Tocopherol).

No yeast, wheat, gluten, soy protein, milk/dairy, corn, starch, artificial coloring, preservatives or flavoring.
Supplement Facts
Serving Size: 1 Tablet
Servings per Container: 100
Amount Per Serving %DV
Vitamin D-3 (cholecalciferol) 5,000 IU 1,250%

Other Ingredients: Cellulose, croscarmellose sodium, calcium carbonate, silica and vegetable stearate.

No yeast, wheat, gluten, soy protein, milk/dairy, corn, starch, artificial coloring, preservatives or flavoring.
UPC Code 310539037959